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References: All-Vita Northwest, 2006. http://www.allvita.net/niacin.htm. Niacin. Retrieved November 21, 2006 from source. Howard Hughes Medical Institute, 2003. http://www.hhmi.org/bulletin/sept2003/cholesterol/century.html. Cholesterol: A Century of Research. Retrieved November 3, 2006 from source. MedicineNet.com. http://www.medicinenet.com/bile_acid_sequestrants/article.htm. Bile acid sequestrants, medications to lower cholesterol on MedicineNet.com. Retrieved October 1, 2006. from source
National Heart Lung and Blood Institute, 2006.
http://www.nhlbi.nih.gov/cgi-bin/chd/step2intro.cgi. TLC Diet. Retrieved
November 13, 2006 from source.
Vitamin Research Products, Inc., 2001. http://intelegen.com/nutrients/niacin.htm. Niacin– The Cholesterol Wars Champion. Retrieved November 21, 2006 from source. Wikipedia.com, 2006. http://en.wikipedia.org/wiki/Niacin. Niacin. Retrieved November 21, 2006 from source. Wrong Diagnosis, 2006. http://www.wrongdiagnosis.com/c/cholesterol/intro.htm. High cholesterol. Retrieved October 13, 2006 from source.
We would also like to thank the following faculty and staff at the University of Arkansas for Medical Sciences College of Pharmacy for helping our team to complete this site:
Dr. Grazyna Nowak for granting the team permission to create the website
Ms. Peggy Griffin for creating the website address
Dr. Martha Carle for her endless hours of help and encouragement in completing the website |
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This is a great site to gather further information on the mechanism of action for Lipitor (the mechanism is the same for all HMG-CoA Reductase Inhibitors). This site also has the information pertaining to clinical trails associated with Lipitor. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202284.html This site can be used to find less detailed but informative information pertaining to all HMG-CoA Reductase Inhibitors. |
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http://archneur.ama-assn.org/cgi/content/abstract/59/3/378 “Serum Lipoprotein Levels, Statin Use, and Cognitive Function in Older Women” |
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http://www.nature.com/ki/journal/v61/n1/abs/4492731a.html “HMG-CoA reductase inhibitors are associated with reduced mortality in ESRD patients” |
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“Statin Therapy Decreases the Risk of Osteonecrosis in Patients Receiving Steroids” |
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http://www.nhlbi.nih.gov/cgi-bin/chd/step2intro.cgi
This link will help a person better understand the TLC Diet as well as other ways that diet influences cholesterol levels. |
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“Watch what you are eating…” are the last words that a patient wants to hear when trying to lower his or her cholesterol, but one of the most successful approaches used in lower cholesterol levels is the Therapeutic Lifestyle Change (TLC) Diet, which is recommended by physicians today. The TLC diet promotes its users to eat healthy as well as participate in physical activity. There are four “rules” when using the TLC diet.
· Saturated fats should be less than 7% of your daily calories. · Fat should encompass only 25-35% of your total daily calories. · One should consume only 200 mg of dietary cholesterol per day. · Limit yourself to only 2400 mg of sodium per day.
You should only consume enough calories per day to keep yourself at a healthy body weight. The TLC diet promotes its users to eat healthy as well as participate in physical activity. The diet divides users into categories based on their levels of LDL and HDL. Each category also considers the dieter’s risk of disease and gives the dieter’s a LDL goal to achieve. (**The information below is referenced directly from wrongdiagnosis.com. See Related Links page for more details.**)
· Category I, Highest Risk- If placed in this category, a person has 100 mg/dL LDL level goal. If at 100 mg/dL or higher, a person must also be place on drug therapy while dieting. · Category II, Next Highest Risk- This category is comprised of people who desire to have a LDL level less than 130 mg/dL. These people should be placed on medications while participating in the diet if they participate in the diet for three months and see no results. · Category III, Moderate Risk- In this category, a person wants their LDL to be 130 mg/dL or less. If LDL is at 160 mg/dL or higher after three months, a person should consider trying a diet other than the TLC diet. · Category IV, Low to Moderate Risk- These people aspire to have a LDL level at 160 mg/dL or less.
The TLC Diet also recommends that a dieter exercise 30 minutes every day.
Another resource to consult pertaining to the TLC Diet is The National Heart Lung and Blood Institute’s website where you can determine if the TLC diet is the proper way for you to lower your cholesterol. The website is located at:http://www.nhlbi.nih.gov/chd/lifestyles.htm This site includes specific information about the TLC Diet as well as informative quizzes about cholesterol and heart disease and activities to help you learn about how much cholesterol you should ingest per day. It also offers a dietary calculator that adjusts your cholesterol level based on your age, your weight, your height, and the amount of exercise perform that you perform daily. For example, an 18-20 year old, 130 pound female that is 5 feet, 5 inches tall who performs light exercise daily should use the following dietary guidelines: Total calories per day: 1800 calories Total saturated fat per day: 12 grams Total grams of fat per day: 60 grams |
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http://www.welchol.com/pdfs/fullPI.pdf
This site gives additional information on the action of Welchol (all bile acid sequestrants have a similar mode of action). This site also provided the information discussed about Welchol clinical trials. |