11. Squalene epoxide is then converted to lanosterol by lanosterol synthase.

Biosynthesis of Cholesterol:

Biochemical Aspects

CoA

O

O

S

H2O

CoA

CoA

O

S

+

Acetyl-CoA

Acetoacetyl-CoA

1. Condensation of Acetyl-CoA and Acetoacetyl-CoA, catalyzed by HMG-CoA synthase, forms HMG-CoA (3-hydroxy-3-methylglutaryl-CoA).

1.